SEXUAL VITALITY
PT-141
Explore a different approach to low sexual desire. Compounded prescription PT-141, with individualized clinician guidance and follow-up included.
From $129/mo
RDT (rapid dissolve)
Tadalafil + Sildenafil RDT
A clinician-selected compounded rapid-dissolve tablet that brings two familiar timing profiles into one individualized prescription.
Your treatment plan
From $49/month equivalent
$147 billed every 3 months3-month commitment$89 billed monthly also availableAll fees includedView plan details
- Licensed clinicians
- Compounded by a licensed 503A pharmacy
- No clinic visit
Questions before you start?
Compare this treatmentWhat will I pay?
Standard plan price$49 per month equivalent, billed $147 every 3 months. 3-month commitment.
Billing options and renewal
The standard Tadalafil + Sildenafil RDT price is $89 billed monthly, or $147 paid up front every three months ($49 per month equivalent; a three-month commitment). These are recurring prices before any eligible first-order discount. A first-order offer reduces that order only; renewal uses the standard price for the chosen plan. A monthly equivalent is not a monthly charge.
What should I know about this treatment?
A clinician-selected compounded rapid-dissolve tablet that brings two familiar timing profiles into one individualized prescription.
Read the evidence and its limitationsWhat should I review before starting?
A licensed clinician reviews your health history and medications and determines whether treatment is appropriate for you.
Read the full Important Safety InformationHow do I request Tadalafil + Sildenafil RDT online?
Complete the online assessment with your health history, current medications and treatment goals. A licensed clinician reviews the information and decides whether to prescribe. If prescribed, a licensed pharmacy prepares and ships your medication.
See how care worksWhat It Is
Combination therapy needs a reason.
Sildenafil and tadalafil are both PDE5 inhibitors. They support penile blood flow in response to sexual stimulation through the same drug class, but their pharmacokinetic profiles are different. Sildenafil is shorter acting. Tadalafil remains active much longer.
This compounded rapid-dissolve tablet puts both molecules into one individually prescribed formulation, bringing their different timing profiles into one dose form selected from your treatment history.
Your provider reviews what you have already tried and decides whether one individually compounded prescription fits your case.
The combination earns its place by addressing a trade-off patients already understand: a shorter timing profile versus a longer one. A clinician, not a cart, decides whether bringing both into one compounded prescription is justified.
Read the evidenceWho It's For
For the case that has already taught you something.
01
The Partial Responder
A standard single-agent approach helped but did not adequately answer the problem. You want the next step based on that history rather than simply repeating it.
02
The Timing-Fit Case
The different duration profiles of sildenafil and tadalafil are relevant to how treatment has worked for you. Your clinician can decide whether combining them has a rationale in your specific case.
03
The Individualized Patient
You are not looking for the strongest item on a menu. You want a provider to decide whether a compounded combination actually earns its place.
This is a medical decision with real trade-offs, and format preference comes second to safety. A licensed clinician screens your full history before prescribing anything.
This might not be the right fit if:
- Any use of nitrate medications, including nitroglycerin and isosorbide; combining PDE5 inhibitors with nitrates can cause a dangerous drop in blood pressure
- Recent heart attack or stroke, or cardiac status your provider considers unstable
- Severe hypotension, or blood pressure that is not adequately controlled
- Alpha-blocker therapy requires provider caution around dosing and timing
- Use of riociguat, or a prior serious reaction to either active ingredient
Your intake screens for all contraindications. Every candidate is evaluated by a licensed clinician before any prescription is issued. No prescription is issued without clearance.
Your Plan
Tadalafil + Sildenafil RDT, prescribed with care.
Compounded by a licensed 503A pharmacy. Prescribed by a licensed provider after clinical review.
- Format
- RDT (rapid dissolve)
- Strength
- Tadalafil 12 mg, sildenafil 60 mg per tablet
- Total plan quantity
- 60 tablets
- Billed amount
- $147 every 3 months
- Monthly equivalent
- $49 per month
- Commitment
- 3 months
- Monthly option
- $89 billed monthly · 20 tablets total plan quantity
- Fees
- Included in the plan price
Strength describes the preparation. Total plan quantity is the amount included in that plan, not your dose or dosing schedule. Follow the directions on your prescription.
Compare billing options and longer-term costs
Compounded by a licensed 503A pharmacy
Tadalafil + Sildenafil RDT
RDT (rapid dissolve)
From $49
Monthly equivalent. All fees included.
$147 billed every 3 months. 3-month commitment.
- Licensed clinician review of cardiovascular history, medications, and prior PDE5 treatment
- Combination prescribed only when the provider identifies a clinical rationale
- Compounded rapid-dissolve tablet prepared by a licensed 503A pharmacy if approved
- Follow-up focused on response, tolerability, and whether the combination continues to earn its place
$49 /mo equivalent · 3-month commitment
$49/mo equivalent, all-in. Consultation is included in the plan price, not added on top. Consultation, cancellation and refund policy.
What happens when I start?
You'll begin an online assessment for Tadalafil + Sildenafil RDT.
- Tell your clinician about you. Share your goals, health history and current medications.
- Review your plan. Confirm the treatment option, billing interval and total shown in the assessment.
- Get an individual clinical review. Your clinician decides whether to prescribe. If prescribed, a licensed pharmacy fulfills your prescription.
Starting an assessment doesn't guarantee a prescription. How care works
Prescription issued subject to provider judgment. Results vary. Not a guarantee of outcomes.
*Price reflects a 3-month commitment. See billing details above.
Your subscription renews at your selected billing interval. Cancel through your member dashboard before the next billing date to stop future charges. Cancellation does not refund the current billing period. See cancellation and refund terms.
Have a question about this plan?
Clinical questions
Message your provider about dosing, side effects, your response or changes in your health.
Open patient portalNew to AnthologyRX? Ask our team about getting started.
The people behind your care
Guidance from the first question onward.
Independent clinical care
Licensed clinicians affiliated with Arora Health & Aesthetics, LLC review your health history, medications and goals, then discuss whether Tadalafil + Sildenafil RDT or another approach fits your needs.
Medical information on this page reviewed by Dr. Dylan Russell, MD, Chief Health Officer on . Your prescribing clinician provides your individual care.
Verify Dr. Russell's medical licensePharmacy quality that matters
Prepared to your prescription by a licensed compounding pharmacy. Our partners have verified quality programs covering identity, potency, independent testing and batch documentation.
Compounded preparations are not FDA-approved. Pharmacy quality controls and your clinician's evaluation of treatment evidence each have a role in your care.
Pharmacy & fulfillment
Listed dispensing pharmacy
- The Pharmacy Hub LLCFormulation: Tadalafil + Sildenafil RDTThis option is not available in South Carolina.Verify: Florida pharmacy license PH33959
Availability depends on your prescription and location. For pharmacy questions, contact our team.
A direct line for follow-up
Message your provider through the patient portal about dosing, side effects, your response or changes in your health. Contact AnthologyRX support for billing, shipment or portal-access help.
The Evidence
What the research shows
Sildenafil alone raised successful intercourse attempts well above placebo.
57 vs 21 percent
successful intercourse attempts on sildenafil versus placebo
The detail
Sildenafil alone has a large randomized record. In a systematic review and meta-analysis of 27 randomized trials covering 6659 men, results pooled from 14 parallel-group flexible-dose trials showed successful intercourse attempts of 57 percent on sildenafil versus 21 percent on placebo, weighted mean difference 33.7, 95 percent confidence interval 29.2 to 38.2, and at least one intercourse success in 83 percent of men versus 45 percent, relative benefit increase 1.8, 95 percent confidence interval 1.7 to 1.9. Every trial in that review tested sildenafil on its own.1
Tadalafil alone raised the erectile-function score and improved erections against placebo.
81 vs 35 percent
reported improved erections on tadalafil versus placebo
The detail
Tadalafil alone has its own. In an integrated analysis of five randomized, double-blind, placebo-controlled 12-week trials in 1112 men of mean age 59, tadalafil 20 mg produced a mean improvement of 7.9 points in the International Index of Erectile Function erectile-function domain, 75 percent of intercourse attempts were completed successfully on Sexual Encounter Profile question 3, and 81 percent reported improved erections versus 35 percent on placebo. Each of those trials tested tadalafil on its own.2
Across 82 trials, every comparison was one PDE5 inhibitor at a time, never two together.
47,626 patients
pooled across 82 randomized trials of single agents
The detail
The two molecules have been compared against each other, one at a time. A network meta-analysis of 82 randomized trials covering 47,626 patients found sildenafil 50 mg the most efficacious starting dose with the highest overall adverse-event rate, and tadalafil 10 mg intermediate in efficacy with the lowest overall adverse-event rate. Every comparison in that analysis is one PDE5 inhibitor against placebo or against another, never two taken together.3
Head to head, tadalafil and sildenafil gave the same erectile-function result.
9.4 to 10.0
least-squares mean improvement across the arms, p equals 0.359
The detail
Where they have been compared head to head in an individual patient population, the erectile-function result was the same. In an open-label randomized study in 770 men new to PDE5 inhibitors assigned to tadalafil once daily, tadalafil on demand or sildenafil on demand, improvement in the erectile-function domain did not differ between arms, least-squares means 9.4 to 10.0, p equals 0.359. The difference between the molecules showed up in how long men stayed on treatment, not in how well they responded.4
What it does not show
No trial has tested this combination, and both labels advise against combining PDE5 inhibitors.
The detail
No trial has tested this combination as sold. There is no published randomized trial of sildenafil and tadalafil taken together in one product for erectile dysfunction, and the approved labeling for both ingredients says so directly. The sildenafil labeling states that the safety and efficacy of combinations with other PDE5 inhibitors or with other treatments for erectile dysfunction have not been studied and that such combinations are not recommended. The tadalafil labeling states that these combinations have not been studied and instructs patients not to take it with another PDE5 inhibitor.56
Every number above came from one molecule alone; none of them transfer to the pairing.
The detail
Because no trial of the pairing exists, none of the numbers above transfer to it. Every reported effect size was produced by one molecule used alone at a studied dose. Putting a second drug from the same class into the same tablet is an additive-pharmacology question rather than a demonstrated gain, and the sildenafil labeling notes specifically that such combinations may further lower blood pressure.125
There is no dose-response evidence for the tier strengths in this compounded formulation.
The detail
There is no dose-response evidence for the tier strengths in this compounded formulation. The doses studied in the trials above are the fixed strengths of the approved single-agent products, and no study has compared a sildenafil and tadalafil combination against either ingredient used alone at an adequate dose.1256
No trial has tested whether rapid-dissolve delivery changes the outcome for either ingredient.
The detail
The evidence and the product are not the same object. Sildenafil and tadalafil are active ingredients in FDA-approved prescription drug products, and the trials cited here were run on those products. This rapid-dissolve combination is compounded to an individual prescription, is not an FDA-approved drug product, and has not been through a trial programme of its own. No trial has tested whether rapid-dissolve delivery changes the outcome for either ingredient.56
- Fink HA, Mac Donald R, Rutks IR, Nelson DB, Wilt TJ. Sildenafil for male erectile dysfunction: a systematic review and… Arch Intern Med. 2002.
- Brock GB, McMahon CG, Chen KK, Costigan T, Shen W, Watkins V, Anglin G, Whitaker S. Efficacy and safety of tadalafil for the treatment of erectile… J Urol. 2002.
- Chen L, Staubli SE, Schneider MP, Kessels AG, Ivic S, Bachmann LM, Kessler TM. Phosphodiesterase 5 inhibitors for the treatment of erectile… Eur Urol. 2015.
- Buvat J, Buttner H, Hatzimouratidis K, Vendeira PA, Moncada I, Boehmer M, Henneges C, Boess FG. Adherence to initial PDE-5 inhibitor treatment: randomized open-label… J Sex Med. 2013.
- FDA-approved prescribing information, VIAGRA (sildenafil citrate) tablets, Pfizer Laboratories Div Pfizer Inc, label published February 2026.DailyMed
- FDA-approved prescribing information, CIALIS (tadalafil) tablets, Eli Lilly and Company, label published June 2026.DailyMed
Important Safety Information
Serious risks
- Approved labeling documents an erection lasting more than four hours
- Sudden decrease or loss of vision in one or both eyes
- Sudden decrease or loss of hearing
- Each of these needs urgent medical attention rather than a wait-and-see approach
Commonly reported
- Headache
- Flushing
- Indigestion
- Nasal congestion
- Back pain
- Muscle aches
Reported effects come from the drug class both ingredients belong to, and are the reactions most often described in approved labeling for sildenafil and tadalafil. Because both molecules lower blood pressure through the same pathway, taking them together concentrates that effect rather than spreading it, which is why your provider reviews nitrates, riociguat, alpha-blockers, other blood-pressure medication and cardiovascular history before prescribing anything. Both active ingredients are well characterized in approved labeling, but this rapid-dissolve combination is compounded to your individual prescription by a licensed 503A pharmacy and is not an FDA-approved drug product. Whether two agents from one class belong in your plan is a decision for the licensed clinician who has your full history and your documented response.
Questions
Asked and answered.
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