THE JOURNAL
Read past the headline.
Know your options. Understand the evidence. Find the answers that matter before you start.
Sexual health
Understand the difference between desire and erections, and compare your treatment options.
- SafetyIs PT-141 safe?
- EvidenceDoes PT-141 work?
- ComparePT-141, sildenafil or tadalafil?
- EvidenceOxytocin nasal spray: what can it change about intimacy?
- Care guideI can get an erection. Why don’t I want sex?
- Care guideMy antidepressant helps my mood. What about my sex life?
- Care guideMy testosterone is normal. Why is my libido low?
- Care guideWe want sex at different frequencies. Where do we start?
- Care guideI want sex, but struggle to orgasm. Could PT-141 help?
- Care guidePT-141 for men: a better conversation about desire
- Care guidePT-141 for women: when desire is what changed
- Care guidePT-141 and gender-affirming hormones: what we know about sexual desire
Tadalafil & erectile health
Compare ED treatment routines, explore real-life questions and understand the research on heart and prostate health.
- CompareDissolving ED tablets: what changes when medicines are combined?
- CompareDaily or on-demand tadalafil? Make the routine work for you.
- CompareSildenafil or tadalafil? Start with the way you live.
- Care guideI want sex. Why isn’t my body cooperating?
- Care guideED in your 30s and 40s: you have options.
- Care guideNew partner. Real chemistry. Too much pressure.
- Care guideYour ED medication isn’t working. What comes next?
- Care guideErectile health for gay and bisexual men: care on your terms.
- EvidenceDaily tadalafil and heart health: why researchers are looking beyond ED
- Care guideTadalafil for ED and enlarged-prostate symptoms: when one medication can address both
- SafetyDaily tadalafil safety: what matters before you start
- EvidenceOn-demand tadalafil: more room for the moment
Weight & metabolic health
Compare medications, formats and the questions to ask before starting a weight-management plan.
- Care guideGLP-1 prices and longer-term costs
- Care guideSwitching GLP-1 providers
- Care guideWhen GLP-1 progress slows
- CompareSemaglutide vs. tirzepatide
- Care guideHow to compare compounded GLP-1 providers
- SafetyIs compounded semaglutide safe?
- CompareCompounded semaglutide vs. Ozempic
- CompareCompounded tirzepatide vs. Mounjaro and Zepbound
- CompareOral semaglutide vs. injections
- EvidenceAre lipotropic injections worth it?
- CompareLipotropic injections vs. GLP-1 medications
- Care guideRetatrutide: research and availability
- EvidenceMetformin for prediabetes and healthy aging: benefits and evidence
Energy & longevity
Look beyond the headline claims: what the research says, how formats differ and where evidence is still developing.
- EvidenceIs NAD+ worth it?
- Care guideNAD+ for fatigue: evidence, expectations and your next step
- CompareNAD+ injections, nasal spray or pills?
- EvidenceNAD+ and aging: what we actually know
- EvidenceDoes glutathione work?
- CompareGlutathione nasal spray or injection: evidence, routine and safety
- CompareGlutathione injections, IV or oral?
- EvidenceThe glutathione antioxidant system
- EvidenceWhat should you know about methylene blue?
- CompareMethylene blue vs. NAD+
- EvidenceIs MOTS-c worth it?
- CompareMOTS-c vs. SS-31
- Care guideCan SS-31 be prescribed?
- EvidenceIs epithalon worth it?
Performance & recovery
Explore the evidence behind peptide care and compare treatments without treating them as interchangeable.
- EvidenceIs sermorelin worth it?
- Care guideSermorelin results: what to expect and how to monitor treatment
- EvidenceTesamorelin for visceral fat: benefits, evidence and treatment goals
- CompareSermorelin, CJC/ipamorelin or tesamorelin?
- EvidenceSermorelin and the growth hormone axis
- EvidenceIs CJC-1295/ipamorelin worth it?
- SafetyCJC-1295/ipamorelin safety
- CompareCJC-1295/ipamorelin vs. IGF-1 LR3
- EvidenceWhat does the IGF-1 LR3 evidence show?
- Care guideCan IGF-1 LR3 be prescribed?
BPC-157 & recovery
Explore the research, compare formats and blends, and connect recovery questions to the life you want to get back to.
- EvidenceBPC-157: what the human research actually shows
- SafetyBPC-157 safety: what to know before you decide
- CompareOral or injectable BPC-157? Start with the evidence.
- Care guideI want to get back to training. Where does BPC-157 fit?
- EvidenceBPC-157 and gut health: ask a more specific question
- Care guideYou lost the weight. Now you want your active life back.
- Care guideRest sounds great. My life doesn’t allow it.
- Care guideMy knee feels better. My stomach doesn’t.
- EvidenceBPC-157 and bladder pain: an unexpected research question
- EvidenceBPC-157 after cosmetic procedures: what’s behind the claims?
- Care guideIt hurts less. Does that mean it’s healed?
- Care guideNothing is injured. Should I take BPC-157 anyway?
- EvidenceWolverine and Wolverine 2.0: what does the research support?
- EvidenceIs KLOW worth it? Make every ingredient earn its place.
- CompareBPC-157, Wolverine, Wolverine 2.0 or KLOW?
- Care guideHow to get BPC-157 prescribed online
- Care guideHow much does BPC-157 cost?
- Care guideResearch-grade vs. compounded BPC-157
Hormones & menopause
Compare estrogen and progesterone options, delivery formats and practical questions about care.
- Care guideYour sex life after menopause: what changes, what can help
- CompareVaginal estrogen or systemic hormone therapy? Start with your symptoms.
- Care guideDo I need progesterone with estrogen?
- CompareEstradiol patches, gel or pills?
- SafetyIs estradiol safe?
- Care guideEstradiol patch availability and alternatives
- EvidenceDoes Biest cream work?
- CompareBiest vs. estradiol
- CompareMicronized progesterone vs. synthetic progestins
Hair & skin
Compare hair-loss treatment routines and examine the evidence behind topical peptide care.
Mind & focus
Understand the questions around Semax and Selank, including the limits of the current research.
Choosing your care
Know who is prescribing, who is dispensing and what to check before you begin.
How we source and review treatment information
