Sermorelin, CJC-1295 with ipamorelin, or tesamorelin? Same system, three different jobs.
All three work upstream, prompting your own growth-hormone rhythm rather than replacing it with synthetic HGH. The differences are in what each is centered on: sermorelin is the single established signal, CJC-1295 with ipamorelin pairs two signals for a fuller push, and tesamorelin is the one studied specifically on visceral fat. A licensed clinician decides which, if any, fits your case.
The short answer
Start from the job, not the molecule. If the goal is recovery and sleep rhythm with the simplest possible plan, sermorelin is the established single signal. If training demands more and you want two signals working the same system, CJC-1295 with ipamorelin is that combination. If the specific concern is deep abdominal fat, tesamorelin is the one with research aimed exactly there.
Side by side
| Sermorelin | CJC-1295 / Ipamorelin | Tesamorelin | |
|---|---|---|---|
| What it is | One established peptide signal | Two peptides on one axis | One peptide, one studied target |
| Centered on | Recovery and sleep rhythm | Recovery for demanding training | Visceral fat biology |
| Complexity | Simplest | Fuller combination | Focused |
| Where it lives | AnthologyRX | AnthologyRX+ (our peptide storefront) | AnthologyRX |
| Monthly cost | From $159/mo | From $179/mo | From $159/mo |
| Regulatory status | Compounded to your prescription; not an FDA-approved drug product | Compounded to your prescription; not an FDA-approved drug product | Compounded to your prescription; not an FDA-approved drug product |
Sermorelin vs HGH: why upstream matters
Synthetic HGH replaces the hormone directly. These three prompt your own production, which keeps your body's feedback rhythm in the loop. That is a different clinical philosophy, and it is the reason this category exists. None of the three is HGH, and none is prescribed here as a substitute for it.
Sermorelin vs TRT
Different systems entirely. TRT addresses testosterone; these address the growth-hormone axis. Some patients discuss both with their clinicians, but neither replaces the other, and this page compares only the growth-hormone options.
Which one do most people start with?
Sermorelin, usually, because a single established signal is the simplest place for a clinician to start and evaluate. But "most people" is not a prescription. The Assessment gives your clinician what they need to say which fits you, including none of them.
Questions
What happens if I am not approved?
You are not charged. Your clinician explains the reasoning and, where useful, what a better next step may be. Reviews are typically completed in under 24 hours.
Are any of these FDA approved?
No compounded medication is FDA-approved, including these. Compounded medicines are made to your individual prescription by a licensed pharmacy rather than manufactured and approved as a finished drug product.
Why is CJC-1295 with ipamorelin on a different site?
AnthologyRX+ is our peptide storefront, with the same clinician review and the same licensed US pharmacy compounding. The link takes you there and says so on the way.
Ready when you are.
About 10 minutes. No charge unless your clinician approves.