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AnthologyRX

Sermorelin

Compounded sermorelin is an upstream growth-hormone signal, not synthetic HGH and not a bodybuilding product.

Your treatment plan

From $119/month equivalent

$357 billed every 3 months3-month commitment$159 billed monthly also availableAll fees includedView plan details
  • Licensed clinicians
  • Compounded by a licensed 503A pharmacy
  • No clinic visit

Questions before you start?

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What will I pay?

Standard plan price$119 per month equivalent, billed $357 every 3 months. 3-month commitment.

Billing options and renewal

The standard Sermorelin price is $159 billed monthly, or $357 paid up front every three months ($119 per month equivalent; a three-month commitment). These are recurring prices before any eligible first-order discount. A first-order offer reduces that order only; renewal uses the standard price for the chosen plan. A monthly equivalent is not a monthly charge.

View full plan details

What should I know about this treatment?

Compounded sermorelin is an upstream growth-hormone signal, not synthetic HGH and not a bodybuilding product.

Read the evidence and its limitations

What should I review before starting?

A licensed clinician reviews your health history and medications and determines whether treatment is appropriate for you.

Read the full Important Safety Information

How do I request Sermorelin online?

Complete the online assessment with your health history, current medications and treatment goals. A licensed clinician reviews the information and decides whether to prescribe. If prescribed, a licensed pharmacy prepares and ships your medication.

See how care works
What It Is

Start upstream.

Growth hormone gets the attention. The signal that tells your pituitary to release it is the more interesting place to start.

Sermorelin is a synthetic analog of growth hormone releasing hormone, or GHRH. Rather than supplying growth hormone directly, it stimulates the pituitary to release the growth hormone your own endocrine system produces. The treatment acts upstream in the signaling chain instead of replacing the downstream hormone.

Growth hormone secretion is naturally pulsatile, and sermorelin works through the physiology that generates those pulses. That does not turn mechanism into a promise about sleep, muscle, recovery, energy, or body composition. It does give the clinician a specific hormonal axis to evaluate when your goals and history make that conversation appropriate.

Sermorelin signals the body's own growth-hormone system rather than supplying synthetic HGH. Its upstream mechanism and slow-build timeline keep the treatment focused on clinician-guided endocrine care.

Read the evidence
Who It's For

For people asking the upstream question.

01

The Recovery Question

Training still matters, but recovery feels different from the baseline you remember. You want a clinician to evaluate the hormonal context rather than assume the answer is simply more effort.

02

The GH-Axis Reader

You understand the difference between administering growth hormone and stimulating its release. You want that physiology discussed seriously, without turning the mechanism into a guaranteed outcome.

03

The Long-Game Patient

You are interested in endocrine health as a system, not a quick performance effect. A provider-guided plan is the only version of that conversation that interests you.

Compounded sermorelin is not an FDA-approved drug product. Sermorelin is not growth hormone; it signals your pituitary to release its own. A licensed provider determines candidacy from your full intake, and results vary.

This might not be the right fit if:
  • You have an active cancer or are in remission. Any active or recent cancer needs oncology clearance before a GH-stimulating plan.
  • You are pregnant or breastfeeding.
  • You have untreated hypothyroidism. Your thyroid needs to be optimized before starting a GH-axis treatment.
  • You have significant pituitary dysfunction or a history of pituitary surgery. That calls for a provider’s evaluation before any GHRH-based treatment.
  • You take a medication or carry a condition that deserves a closer look before adding an injectable peptide.

Your intake screens for all contraindications. Every candidate is evaluated by a licensed clinician before any prescription is issued. No prescription is issued without clearance.

Your Plan

Sermorelin, prescribed with care.

Compounded by a licensed 503A pharmacy. Prescribed by a licensed provider after clinical review.

One price covers your consultation, provider review, medication if prescribed, pharmacy fulfillment, shipping and follow-up. All fees included.
Format
Injection
Strength
3 mg/mL
Total plan quantity
15 mL
Billed amount
$357 every 3 months
Monthly equivalent
$119 per month
Commitment
3 months
Monthly option
$159 billed monthly · 5 mL total plan quantity
Fees
Included in the plan price

Strength describes the preparation. Total plan quantity is the amount included in that plan, not your dose or dosing schedule. Follow the directions on your prescription.

Your subscription renews at your selected billing interval. Cancel through your member dashboard before the next billing date to stop future charges. Cancellation does not refund the current billing period. See cancellation and refund terms.

Have a question about this plan?

Billing

Our support team can help with plan prices, billing and portal access.

Ask about billing

Shipping

Contact AnthologyRX support for help checking a shipment.

Get shipment help

Clinical questions

Message your provider about dosing, side effects, your response or changes in your health.

Open patient portal

New to AnthologyRX? Ask our team about getting started.

The people behind your care

Guidance from the first question onward.

Independent clinical care

Licensed clinicians affiliated with Arora Health & Aesthetics, LLC review your health history, medications and goals, then discuss whether Sermorelin or another approach fits your needs.

Medical information on this page reviewed by Dr. Dylan Russell, MD, Chief Health Officer on . Your prescribing clinician provides your individual care.

Verify Dr. Russell's medical license

Pharmacy quality that matters

Prepared to your prescription by a licensed compounding pharmacy. Our partners have verified quality programs covering identity, potency, independent testing and batch documentation, with sterility and endotoxin controls for injectable preparations.

Compounded preparations are not FDA-approved. Pharmacy quality controls and your clinician's evaluation of treatment evidence each have a role in your care.

Pharmacy & fulfillment

Listed dispensing pharmacy

Availability depends on your prescription and location. For pharmacy questions, contact our team.

Explore our pharmacy quality standards

A direct line for follow-up

Message your provider through the patient portal about dosing, side effects, your response or changes in your health. Contact AnthologyRX support for billing, shipment or portal-access help.

The Evidence

What the research shows

Open-label study · 110 children · 12 months

In children with growth hormone deficiency, height velocity rose from 4.1 to 8.0 cm a year.

4.1 to 8.0
centimeters per year of height velocity, baseline to 6 months
The detail

In a multicenter open-label study, 110 previously untreated prepubertal children with growth hormone deficiency received sermorelin, GHRH(1-29), at 30 micrograms per kilogram subcutaneously once nightly, and mean height velocity rose from 4.1 centimeters per year at baseline to 8.0 at 6 months and 7.2 at 12 months.1

Randomized crossover study · 10 men · 14 days

GHRH raised growth hormone and IGF-1 to levels seen in healthy young men.

No longer different
24-hour growth hormone and IGF-1 from healthy young men, at the 1 milligram dose
The detail

In a randomized crossover study in 10 healthy men of mean age 68, GHRH(1-29) self-injected subcutaneously twice daily for 14 days raised mean 24-hour growth hormone and IGF-1 at the 1 milligram dose to levels no longer different from those measured in healthy young men, with no change in fasting glucose, blood pressure, or chemistry and hematology profiles.2

Open study · 11 men · six weeks

Nightly GHRH raised nocturnal growth hormone but did not change IGF-1, weight or DEXA measures.

2 of 6
measures of muscle strength that improved in the study
The detail

In an open six-week study in 11 healthy non-obese men aged 64 to 76 with low baseline IGF-1, nightly self-injected GHRH(1-29) at 2 milligrams increased mean nocturnal growth hormone release and growth hormone peak amplitude but did not change IGF-1, IGF binding protein 3, body weight, or DEXA measures of muscle and fat; 2 of 6 measures of muscle strength improved.3

Single-blind randomized placebo-controlled study · 19 adults · 16 weeks

Lean body mass rose in the men only, and the IGF-1 rise faded by week 16.

19 adults · 16 weeks
men and women aged 55 to 71 on nightly dosing
The detail

In a single-blind, randomized, placebo-controlled study in 19 men and women aged 55 to 71, 16 weeks of nightly [Nle27]GHRH(1-29)NH2 at 10 micrograms per kilogram increased nocturnal growth hormone, IGF-1 and skin thickness, and increased lean body mass in the men only, while body weight and self-reported sleep quality were unchanged and the IGF-1 rise returned toward baseline by week 16.4

What it does not show

Evidence gap · compounded sermorelin

No randomized trial has tested compounded sermorelin for sleep, recovery, energy or aging.

The detail

There are no randomized controlled trials establishing that compounded sermorelin improves sleep, recovery, energy, body composition or any aging outcome in adults who do not have diagnosed growth hormone deficiency.

Applicability · population

The height-velocity result came from children with diagnosed deficiency and had no control group.

The detail

The height-velocity result comes from prepubertal children with diagnosed growth hormone deficiency in an open-label study without a control group. That is a different population, indication and endpoint from adult use.

Intermediates versus outcomes

Growth hormone and IGF-1 are intermediates; weight, fat mass and sleep did not change.

The detail

Growth hormone and IGF-1 are measured intermediates, not clinical outcomes. In the adult studies above the hormone response was not accompanied by a change in body weight or in fat mass, sleep quality was unaffected, and in one study nightly dosing raised growth hormone without raising IGF-1 at all.

Applicability · study size and length

The compounded preparation is not the discontinued approved product, and the adult studies were small.

10 to 19 people
group sizes in adult GHRH studies running 2 weeks to 5 months
The detail

Geref, the sermorelin product that once held an approved United States label, has been discontinued; the compounded preparation offered here is not that product and has not been studied as a finished drug product. The adult GHRH studies cited here ran from 2 weeks to 5 months in groups of 10 to 19 people, which is too small and too short to describe long-term safety or benefit.

  1. Thorner M, et al. Once daily subcutaneous growth hormone-releasing hormone therapy… J Clin Endocrinol Metab. 1996.
  2. Corpas E, et al. Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the… J Clin Endocrinol Metab. 1992.
  3. Vittone J, et al. Effects of single nightly injections of growth hormone-releasing… Metabolism. 1997.
  4. Khorram O, et al. Endocrine and metabolic effects of long-term administration of… J Clin Endocrinol Metab. 1997.
Important Safety Information

Serious risks

  • A large proportion of treated patients developed antibodies to the peptide, an effect whose clinical significance was never established
  • Sermorelin is prohibited at all times by the World Anti-Doping Agency, so if you are a tested athlete, say so at intake

Commonly reported

  • Mostly local: pain, swelling or redness where you inject, the most common finding on the brand label before that product was discontinued
  • Reported less often: flushing, headache, nausea, dizziness, drowsiness, difficulty swallowing and hives

Because sermorelin works by pushing your own pituitary to release growth hormone, your provider screens for active or recent cancer, for pituitary disease or prior pituitary surgery, and for untreated hypothyroidism, which is addressed before a growth hormone axis treatment starts. The compounded preparation offered here is not the discontinued labeled product, and safety data for using it this way is limited, which is the reason this sits with a clinician rather than in a shopping cart.

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