CELLULAR DEFENSE
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Topical cream
GHK-Cu Copper Peptide Cream
Prescription-compounded GHK-Cu 2% (20 mg/g) cream, with clinician review of your skin and current routine.
Your treatment plan
From $139/month equivalent
$417 billed every 3 months3-month commitment$169 billed monthly also availableAll fees includedView plan details
- Licensed clinicians
- Compounded by a licensed 503A pharmacy
- No clinic visit
Questions before you start?
Compare this treatmentWhat will I pay?
Standard plan price$139 per month equivalent, billed $417 every 3 months. 3-month commitment.
Billing options and renewal
The standard GHK-Cu Copper Peptide Cream price is $169 billed monthly, or $417 paid up front every three months ($139 per month equivalent; a three-month commitment). These are recurring prices before any eligible first-order discount. A first-order offer reduces that order only; renewal uses the standard price for the chosen plan. A monthly equivalent is not a monthly charge.
What should I know about this treatment?
Prescription-compounded GHK-Cu 2% (20 mg/g) cream, with clinician review of your skin and current routine.
Read the evidence and its limitationsWhat should I review before starting?
A licensed clinician reviews your health history and medications and determines whether treatment is appropriate for you.
Read the full Important Safety InformationHow do I request GHK-Cu Copper Peptide Cream online?
Complete the online assessment with your health history, current medications and treatment goals. A licensed clinician reviews the information and decides whether to prescribe. If prescribed, a licensed pharmacy prepares and ships your medication.
See how care worksWhat It Is
Skin is tissue before it is a surface.
GHK-Cu has spent decades moving between serious skin research and increasingly enthusiastic cosmetic marketing. The molecule itself is more interesting than the hype around it.
GHK is a naturally occurring tripeptide that binds copper. In skin and connective-tissue research, the GHK-Cu complex has been studied in signaling related to collagen synthesis and tissue remodeling. That puts the peptide upstream of the way skin is usually marketed: not as another ingredient that sits on the surface, but as a molecule researchers have examined in the biology of the tissue underneath it.
The prescription version does not need to pretend every copper-peptide claim on the internet is true. Its value is more disciplined. Your clinician can look at your skin, your current actives, your sensitivity history, and the rest of your routine before deciding whether a compounded GHK-Cu cream belongs in it.
This page offers GHK-Cu 2% (20 mg/g) cream. Your clinician reviews how it fits your skin, your current products and the rest of your routine before deciding whether to prescribe.
Read the evidenceWho It's For
For skincare that has become too informed for another impulse buy.
01
The Ingredient Reader
You already know what peptides, retinoids, vitamin C, and acids are supposed to do. You want the next decision based on your actual skin rather than another ingredient trend.
02
The Routine Graduate
You have built the over-the-counter basics correctly and are ready to ask whether a prescription-compounded option belongs in the plan. The point is not more steps. It is a more deliberate one.
03
The Sensitive Optimizer
Your routine works until too many active products start competing with each other. You want a clinician to look at sequencing, tolerance, and whether GHK-Cu adds something useful without turning the bathroom shelf into a chemistry experiment.
Compounded GHK-Cu cream is not an FDA-approved drug product. A licensed clinician evaluates it against your skin history and goals, and results vary.
This might not be the right fit if:
- Known copper sensitivity or Wilson’s disease
- Active skin infection at the application site
- Pregnancy, unless cleared by your provider
Your intake screens for all contraindications. Every candidate is evaluated by a licensed clinician before any prescription is issued. No prescription is issued without clearance.
Your Plan
GHK-Cu Copper Peptide Cream, prescribed with care.
Compounded by a licensed 503A pharmacy. Prescribed by a licensed provider after clinical review.
- Format
- Topical cream
- Strength
- 2% (20 mg/g)
- Total plan quantity
- 90 g
- Billed amount
- $417 every 3 months
- Monthly equivalent
- $139 per month
- Commitment
- 3 months
- Monthly option
- $169 billed monthly · 30 g total plan quantity
- Fees
- Included in the plan price
Strength describes the preparation. Total plan quantity is the amount included in that plan, not your dose or dosing schedule. Follow the directions on your prescription.
Compare billing options and longer-term costs
Compounded by a licensed 503A pharmacy
GHK-Cu Copper Peptide Cream
Topical cream
From $139
Monthly equivalent. All fees included.
$417 billed every 3 months. 3-month commitment.
- Compounded GHK-Cu facial cream prepared to your individual prescription
- Applied in the evening as directed by your provider
- Existing active skincare reviewed for sequencing and tolerance
- Prepared by a licensed 503A pharmacy
- Response and routine reviewed through your ongoing provider relationship
$139 /mo equivalent · 3-month commitment
$139/mo equivalent, all-in. Consultation is included in the plan price, not added on top. Consultation, cancellation and refund policy.
What happens when I start?
You'll begin an online assessment for GHK-Cu Copper Peptide Cream.
- Tell your clinician about you. Share your goals, health history and current medications.
- Review your plan. Confirm the treatment option, billing interval and total shown in the assessment.
- Get an individual clinical review. Your clinician decides whether to prescribe. If prescribed, a licensed pharmacy fulfills your prescription.
Starting an assessment doesn't guarantee a prescription. How care works
Prescription issued subject to provider judgment. Results vary. Not a guarantee of outcomes.
*Price reflects a 3-month commitment. See billing details above.
Your subscription renews at your selected billing interval. Cancel through your member dashboard before the next billing date to stop future charges. Cancellation does not refund the current billing period. See cancellation and refund terms.
Have a question about this plan?
Clinical questions
Message your provider about dosing, side effects, your response or changes in your health.
Open patient portalNew to AnthologyRX? Ask our team about getting started.
The people behind your care
Guidance from the first question onward.
Independent clinical care
Licensed clinicians affiliated with Arora Health & Aesthetics, LLC review your health history, medications and goals, then discuss whether GHK-Cu Copper Peptide Cream or another approach fits your needs.
Medical information on this page reviewed by Dr. Dylan Russell, MD, Chief Health Officer on . Your prescribing clinician provides your individual care.
Verify Dr. Russell's medical licensePharmacy quality that matters
Prepared to your prescription by a licensed compounding pharmacy. Our partners have verified quality programs covering identity, potency, independent testing and batch documentation.
Compounded preparations are not FDA-approved. Pharmacy quality controls and your clinician's evaluation of treatment evidence each have a role in your care.
Pharmacy & fulfillment
Listed dispensing pharmacy
- The Pharmacy Hub LLCFormulation: 2% creamVerify: Florida pharmacy license PH33959
Availability depends on your prescription and location. For pharmacy questions, contact our team.
A direct line for follow-up
Message your provider through the patient portal about dosing, side effects, your response or changes in your health. Contact AnthologyRX support for billing, shipment or portal-access help.
The Evidence
What the research shows
GHK-Cu stimulated collagen synthesis in fibroblasts at very low concentrations.
10 to the minus 9 molar
concentration at which collagen stimulation reached a maximum
The detail
The mechanism is characterized in cell culture. In fibroblast cultures, the copper complex of the tripeptide glycyl-L-histidyl-L-lysine stimulated collagen synthesis at very low concentrations, with the effect beginning between 10 to the minus 12 and 10 to the minus 11 molar and reaching a maximum at 10 to the minus 9 molar, independent of any change in cell number.1
Injected GHK-Cu raised collagen and protein in rat wound chambers; a control tripeptide did not.
The detail
In rats carrying stainless steel wire mesh wound chambers implanted under the skin, sequential injections of GHK-Cu into the chamber produced a concentration-dependent increase in dry weight, DNA, total protein, collagen and glycosaminoglycan content, with type I and type III collagen messenger RNA increased, while a control tripeptide had no significant effect.2
Copper-GHK increased keratinocyte proliferation and raised p63 and integrin expression.
The detail
In monolayer keratinocyte cultures and in skin-equivalent models, copper-GHK increased keratinocyte proliferation and raised expression of proliferating cell nuclear antigen, p63 and integrins alpha6 and beta1.3
In diabetic neuropathic ulcers, GHK-Cu gel closed more wound area than vehicle.
98.5% vs 60.8%
median area closure of plantar ulcers on gel versus vehicle
The detail
The one randomized human trial of GHK-Cu is in wounds rather than in facial skin. A multicenter, randomized, evaluator-blinded, placebo-controlled study in patients with diabetic neuropathic ulcers found that a topical GHK-Cu gel raised median area percentage closure of plantar ulcers to 98.5 percent compared with 60.8 percent for vehicle, P less than 0.05, and lowered the incidence of ulcer infection to 7 percent from 34 percent, P less than 0.05.4
Copper from GHK-Cu crossed excised human skin and left a depot in the tissue.
136 micrograms
of copper per square centimeter through dermatomed skin over 48 hours
The detail
Copper from GHK-Cu does move into skin in the laboratory. In flow-through diffusion cells using excised human skin, a 0.68 percent aqueous copper tripeptide solution applied for 48 hours delivered 136 micrograms of copper per square centimeter through dermatomed skin, with a further 97 micrograms per square centimeter retained in the tissue as a depot.5
What it does not show
No FDA-approved GHK-Cu product exists, and no study above tested a prescription facial cream.
The detail
There is no FDA-approved GHK-Cu drug product, and a compounded cream is not an FDA-approved drug product. None of the work above tested a prescription facial cream against visible aging in people.
A 2025 review found a surprising absence of clinical studies using GHK-Cu.
20 people
the 1998 pilot study applied creams to the thigh for one month
The detail
A 2025 review of topically applied GHK as an anti-wrinkle peptide concluded that, despite how widely the peptide is used in cosmetic products, there is a surprising absence of clinical studies using GHK-Cu. The human facial data the review was able to identify were a 1998 pilot study in 20 people who applied creams to the thigh for one month and two 2002 American Academy of Dermatology conference proceedings, none of them published as full randomized trials.6
Closing an ulcer does not establish a change in wrinkle depth or firmness on a face.
The detail
The randomized human evidence is in a different tissue state, a different formulation and a different endpoint: an open ulcer in a person with diabetes, treated with a gel, measured by wound closure. Closing an ulcer does not establish a change in wrinkle depth, skin density or firmness on a face.4
No published study reports what a cream in normal use delivers to living human dermis.
The detail
The collagen findings come from fibroblast cultures and from rat wound chambers dosed by direct injection, and the permeation data come from excised human skin mounted in diffusion cells. No published study reports what concentration of GHK-Cu reaches living human dermis from a cream in normal use, or what visible change follows when it does.1256
- Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by the… FEBS Lett. 1988.
- Maquart FX, Bellon G, Chaqour B, et al. In vivo stimulation of connective tissue accumulation by the… J Clin Invest. 1993.
- Kang YA, Choi HR, Na JI, et al. Copper-GHK increases integrin expression and p63 positivity by… Arch Dermatol Res. 2009.
- Mulder GD, Patt LM, Sanders L, et al. Enhanced healing of ulcers in patients with diabetes by topical… Wound Repair Regen. 1994.
- Hostynek JJ, Dreher F, Maibach HI. Human skin penetration of a copper tripeptide in vitro as a function of… Inflamm Res. 2011.
- Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR. Topically applied GHK as an anti-wrinkle peptide: advantages, problems… Bioimpacts. 2025.
Important Safety Information
Serious risks
- GHK-Cu delivers copper to the skin, so your provider asks about Wilson disease and other disorders of copper handling
- Known copper sensitivity
- Copper you already take in supplements
Commonly reported
- Redness
- Stinging
- Itching
- Dryness
- Occasionally allergic contact dermatitis, which with this formulation can also be a reaction to copper itself
Because it is a topical cream
- Your provider reviews the rest of your routine, since retinoids, acids and other actives are a common reason skin becomes irritated in the first place
Reported effects from a topical peptide cream are local. There is no FDA-approved GHK-Cu drug product, and controlled human safety data for topical copper peptides are limited, so the honest description is a well-studied molecule with a thin clinical safety file rather than a proven prescription therapy. The cream is compounded to your individual prescription by a licensed 503A pharmacy, and whether it belongs in your routine is a decision made with a licensed clinician who has your skin history in front of them.
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