Your cells are running on empty.

Oral NAD+ precursors. NMN, NR, and nicotinamide. Must survive the gastrointestinal tract and be converted to NAD+ through enzymatic pathways before becoming bioavailable to cells. Research suggests this process results in significant degradation, and the amount of NAD+ that reaches systemic circulation from oral supplementation is substantially lower than what you take. Subcutaneous injection delivers the compound directly into tissue, bypassing GI degradation entirely. The result is meaningfully higher bioavailability. Which is why the injectable form is prescribed and managed by a clinician rather than sold over the counter. The dose and delivery method make the difference.

Response timelines vary by individual and are not guaranteed. Many patients report early changes in energy quality and sleep. Often within the first two to four weeks. Cognitive improvements and recovery changes tend to emerge over four to eight weeks as NAD+ levels are progressively restored. The most measurable changes are typically reported at the eight-to-twelve week mark. This is not a stimulant. It doesn't produce an acute effect. It works by restoring cellular substrate over time. Your provider will check in monthly and adjust dosing if your response is not progressing as expected.

NAD+ is commonly prescribed alongside Glutathione and Lipo-C for patients pursuing comprehensive longevity and metabolic health. The mechanisms are distinct and generally complementary. NAD+ addresses cellular energy and DNA repair, Glutathione drives antioxidant defense and detoxification, and Lipo-C supports fat metabolism and liver function. Your clinician reviews all active medications, supplements, and protocols at intake and evaluates compatibility case by case. Stacking is not automatic. It requires clinical clearance. Disclose all current treatments during your intake assessment so your provider can design the appropriate sequence.

Lab work is not universally required to start NAD+ therapy, but your provider may request baseline labs depending on your health history and intake responses. If you have underlying conditions. Particularly kidney or liver disease. Your provider will require a clinical review of relevant labs before issuing a prescription. If you have recent bloodwork, noting your results during intake can be helpful context. Your clinician makes the determination about what additional screening is needed based on your individual clinical picture. There is no standard lab panel required for NAD+ across all patients.

NAD+ is administered as a subcutaneous injection. The same technique used for insulin administration. Your first shipment includes detailed injection instructions and all necessary supplies: pre-filled or multi-dose vials, syringes, and alcohol prep pads. Subcutaneous injection involves introducing a small needle just under the skin. Typically in the abdomen or thigh. At a shallow angle. Most patients are comfortable with the process within the first one to two self-administrations. If you have any questions or concerns after receiving your supplies, your care team is reachable via direct message and will walk you through the technique.

Dosing is determined by your prescribing clinician based on your individual health history, goals, body weight, and clinical presentation. It is not a fixed protocol applied uniformly. NAD+ subcutaneous doses are typically initiated at a lower level and adjusted based on your tolerance and response. Your provider may titrate your dose upward over the first few months as your clinical picture develops. Because this is a clinician-prescribed compound, dosing is tailored. Not standardized. You will receive your specific dose information with your prescription documentation and can discuss adjustments with your care team at any monthly check-in.