METABOLIC
Semaglutide
Explore compounded semaglutide injections for weight management, with clinical review, medication, shipping and ongoing care in one monthly plan.
From $129/mo
Injection
Semaglutide + B12 Microdose
A lower-dose compounded semaglutide and vitamin B12 injection, with individual prescribing, pharmacy fulfillment and follow-up.
Your treatment plan
From $109/month equivalent
$327 billed every 3 months3-month commitment$129 billed monthly also availableAll fees includedView plan details
- Licensed clinicians
- Compounded by a licensed 503A pharmacy
- No clinic visit
Alternate dosage forms are compounded only where a licensed clinician documents a patient-specific clinical need that a commercially available product cannot meet. They are not interchangeable with, and are not substitutes for, FDA-approved products. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality.
Questions before you start?
Compare this treatmentWhat will I pay?
Standard plan price$109 per month equivalent, billed $327 every 3 months. 3-month commitment.
Billing options and renewal
The standard Semaglutide + B12 Microdose price is $129 billed monthly, or $327 paid up front every three months ($109 per month equivalent; a three-month commitment). These are recurring prices before any eligible first-order discount. A first-order offer reduces that order only; renewal uses the standard price for the chosen plan. A monthly equivalent is not a monthly charge.
What should I know about this treatment?
A lower-dose compounded semaglutide and vitamin B12 injection, with individual prescribing, pharmacy fulfillment and follow-up.
Read the evidence and its limitationsWhat should I review before starting?
Boxed warning
FDA-approved semaglutide products carry a boxed warning concerning thyroid C-cell tumors observed in rodents. That warning is why a personal or family history of medullary thyroid carcinoma or MEN 2 is a contraindication.
A licensed clinician reviews your health history and medications and determines whether treatment is appropriate for you.
Read the full Important Safety InformationHow do I request Semaglutide + B12 Microdose online?
Complete the online assessment with your health history, current medications and treatment goals. A licensed clinician reviews the information and decides whether to prescribe. If prescribed, a licensed pharmacy prepares and ships your medication.
See how care worksWhat It Is
A lower dose is still an individual decision.
This compounded injection combines semaglutide and vitamin B12. “Microdose” is the name used for this lower-dose option; it is not a standardized FDA-approved GLP-1 dosing category.
Your clinician considers your treatment history, response, tolerability and the medical reason for the combination. The prescribed dose comes from that evaluation, not from the product name or an online dosing chart.
Vitamin B12 is an essential nutrient. Adding it does not establish greater weight loss or fewer side effects, and a lower dose does not guarantee the results reported for approved medicines.
Your plan includes clinical review, prescribed medication, pharmacy fulfillment, shipping and care-team messaging. This compounded preparation is not FDA-approved.
Read the evidenceWho It's For
For the case where individualization has a clinical reason.
01
The Sensitive Responder
Prior medication tolerability is part of your medical history, not a personality trait. You want the formulation decision made with that history in view rather than assuming the standard path fits everyone.
02
The Individualized Case
A clinician has a specific reason to consider a compounded combination rather than a standard finished product. The reason comes from the case, not from a preference for “microdosing.”
03
The Holding Pattern
During care, a provider may determine that a reduced-dose phase fits the patient's current clinical picture. The dose is set by the provider and is not an entry point selected at signup.
This lower-dose compounded preparation is not FDA-approved. Your clinician evaluates the individual need for the formulation; lower dosing does not guarantee fewer side effects.
This might not be the right fit if:
- Personal or family history of medullary thyroid carcinoma or MEN 2
- History of pancreatitis
- Pregnancy, planned pregnancy, or breastfeeding
- Hypersensitivity to cobalt or vitamin B12
Your intake screens for all contraindications. Every candidate is evaluated by a licensed clinician before any prescription is issued. No prescription is issued without clearance.
Your Plan
Semaglutide + B12 Microdose, prescribed with care.
Compounded by a licensed 503A pharmacy. Prescribed by a licensed provider after clinical review.
- Format
- Injection
- Strength
- Semaglutide 1 mg/mL with B12
- Total plan quantity
- 3 vials
- Billed amount
- $327 every 3 months
- Monthly equivalent
- $109 per month
- Commitment
- 3 months
- Monthly option
- $129 billed monthly · 1 vial total plan quantity
- Fees
- Included in the plan price
Strength describes the preparation. Total plan quantity is the amount included in that plan, not your dose or dosing schedule. Follow the directions on your prescription.
Compounded by a licensed 503A pharmacy
Semaglutide + B12 Microdose
Injection
From $109
Monthly equivalent. All fees included.
$327 billed every 3 months. 3-month commitment.
- Clinician review of your Assessment, medications, history, goals, and prior tolerability
- Individual prescribing decision on whether the compounded semaglutide and B12 combination is appropriate
- Preparation by a licensed 503A pharmacy if approved
- Treatment changes remain clinician-directed rather than self-selected
- Ongoing follow-up connected to the broader metabolic plan
$109 /mo equivalent · 3-month commitment
$109/mo equivalent, all-in. Consultation is included in the plan price, not added on top. Consultation, cancellation and refund policy.
What happens when I start?
You'll begin an online assessment for Semaglutide + B12 Microdose.
- Tell your clinician about you. Share your goals, health history and current medications.
- Review your plan. Confirm the treatment option, billing interval and total shown in the assessment.
- Get an individual clinical review. Your clinician decides whether to prescribe. If prescribed, a licensed pharmacy fulfills your prescription.
Starting an assessment doesn't guarantee a prescription. How care works
Alternate dosage forms are compounded only where a licensed clinician documents a patient-specific clinical need that a commercially available product cannot meet. They are not interchangeable with, and are not substitutes for, FDA-approved products. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality.
*Price reflects a 3-month commitment. See billing details above.
Your subscription renews at your selected billing interval. Cancel through your member dashboard before the next billing date to stop future charges. Cancellation does not refund the current billing period. See cancellation and refund terms.
Have a question about this plan?
Clinical questions
Message your provider about dosing, side effects, your response or changes in your health.
Open patient portalNew to AnthologyRX? Ask our team about getting started.
Care and cost
Clear pricing. Care that follows through.
Your plan brings the clinical review, prescribed medication, pharmacy fulfillment, shipping and care-team messaging together. The consultation is included in your plan price.
- What will I pay at the start and on renewal?
- $129 billed monthly, or $327 paid up front every three months ($109/month equivalent; three-month commitment). These are the standard recurring prices, before any eligible first-order discount. The monthly equivalent is not a monthly charge.
- Does a dose change affect the price?
- The displayed price is for the Semaglutide + B12 Microdose plan and selected billing interval. Confirm the prescribed strength, quantity and price before starting or changing treatment. Moving to a different product or formulation can change the cost. Your clinician decides whether a dose change is appropriate.
- How is this formulation different?
- This lower-dose injection combines semaglutide with vitamin B12. “Microdose” is not a standardized FDA-approved dosing category. Your clinician evaluates the reason for this combination and the prescribed dose. Explore our other semaglutide preparations: Semaglutide injections or Dissolving tablets. Each requires its own clinical evaluation.
- Who helps when I have a question?
- Use the patient portal for questions about dosing, side effects or changes in your health. AnthologyRX support can help with billing, shipping and portal access.
The people behind your care
Guidance from the first question onward.
Independent clinical care
Licensed clinicians affiliated with Arora Health & Aesthetics, LLC review your health history, medications and goals, then discuss whether Semaglutide + B12 Microdose or another approach fits your needs.
Medical information on this page reviewed by Dr. Dylan Russell, MD, Chief Health Officer on . Your prescribing clinician provides your individual care.
Verify Dr. Russell's medical licensePharmacy quality that matters
Prepared to your prescription by a licensed compounding pharmacy. Our partners have verified quality programs covering identity, potency, independent testing and batch documentation, with sterility and endotoxin controls for injectable preparations.
Compounded preparations are not FDA-approved. Pharmacy quality controls and your clinician's evaluation of treatment evidence each have a role in your care.
Pharmacy & fulfillment
Listed dispensing pharmacy
- BelieveRXFormulation: Semaglutide + B12 Microdose, injectionVerify: Texas pharmacy license 35264
Availability depends on your prescription and location. For pharmacy questions, contact our team.
A direct line for follow-up
Message your provider through the patient portal about dosing, side effects, your response or changes in your health. Contact AnthologyRX support for billing, shipment or portal-access help.
The Evidence
What the research shows
GLP-1 is a gut hormone released after meals and cleared very rapidly.
The detail
Glucagon-like peptide-1 is a 30-amino-acid peptide hormone produced in intestinal epithelial endocrine L-cells by differential processing of proglucagon, released in response to meal intake, and inactivated extremely rapidly by the enzyme dipeptidyl peptidase-4.1
It drives glucose-dependent insulin secretion, slows gastric emptying and promotes satiety.
The detail
As an incretin it is secreted within minutes of nutrient ingestion, and incretin-receptor activation on pancreatic islet beta-cells leads to glucose-dependent insulin secretion, while glucagon-like peptide-1 additionally exerts glucoregulatory action through slowing of gastric emptying and glucose-dependent inhibition of glucagon secretion and promotes satiety.2
Semaglutide is a GLP-1 analogue with an elimination half-life of about one week.
The same receptor
semaglutide, a GLP-1 analogue, selectively binds to and activates the GLP-1 receptor
The detail
Semaglutide is a GLP-1 analogue with 94 percent sequence homology to human GLP-1 that selectively binds to and activates the GLP-1 receptor, and FDA labeling describes the resulting mechanism as glucose-dependent stimulation of insulin secretion and lowering of glucagon secretion with a minor delay in early postprandial gastric emptying, and identifies albumin binding as the principal mechanism of protraction behind an elimination half-life of approximately one week.3
Labeling describes GLP-1 as an appetite regulator acting in the brain.
The detail
FDA labeling further describes glucagon-like peptide-1 as a physiological regulator of appetite and caloric intake, states that the GLP-1 receptor is present in several areas of the brain involved in appetite regulation, and reports that animal studies show semaglutide distributed to and activated neurons in brain regions involved in regulation of food intake.4
B12 is labeled as essential to growth, cell reproduction, hematopoiesis and myelin synthesis.
The detail
Vitamin B12 is described in cyanocobalamin injection labeling as essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis, and cyanocobalamin is quantitatively and rapidly absorbed from intramuscular and subcutaneous injection sites, then transported by the binding proteins transcobalamin I and II to the tissues.5
What it does not show
A compounded preparation is not an FDA-approved drug product.
The detail
A compounded preparation is not an FDA-approved drug product: FDA states that compounded drugs are not FDA-approved and that the agency does not verify the safety, effectiveness or quality of compounded drugs before they are marketed.6
Everything above is mechanism, not outcome.
The detail
No trial results are cited here. Everything above is drawn from the clinical pharmacology section of FDA labeling, which describes how the molecule acts. This block deliberately stops there rather than reproducing the separate clinical studies section in which trial results for FDA-approved finished drug products are reported, because a described pathway is not a measured outcome.3
B12 labeling describes no effect on body weight, appetite or energy expenditure.
The detail
Cyanocobalamin injection labeling confines its indications to vitamin B12 deficiency due to malabsorption and to use in the vitamin B12 absorption test, and it describes no effect of vitamin B12 on body weight, appetite or energy expenditure.5
Adding B12 to semaglutide has no established effect; FDA has not evaluated the combination.
FDA advises compounded drugs only when no approved drug fits, and flags equivalence claims.
The detail
FDA advises that compounded drugs should be used only in patients whose medical needs cannot be met by an FDA-approved drug, and identifies a claim that a compounded drug is the same as an FDA-approved drug as a warning sign for consumers.7
- Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev. 2007.
- Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007.
- FDA-approved semaglutide injection prescribing information, section…DailyMed
- FDA-approved semaglutide prescribing information, section 12.1…DailyMed
- FDA-approved cyanocobalamin injection, USP prescribing information…DailyMed
- FDA, Compounding and the FDA: Questions and Answers.FDA
- FDA, Concerns with Unapproved GLP-1 Drugs Used for Weight Loss.FDA
Important Safety Information
Boxed warning
FDA-approved semaglutide products carry a boxed warning concerning thyroid C-cell tumors observed in rodents. That warning is why a personal or family history of medullary thyroid carcinoma or MEN 2 is a contraindication.
Do not use if you have
- A personal or family history of medullary thyroid carcinoma or MEN 2
- Sensitivity to cobalt or vitamin B12
Serious risks
- Pancreatitis
- Gallbladder disease
- Acute kidney injury following the fluid loss that severe vomiting or diarrhea can cause
- Serious hypersensitivity reactions have been reported after parenteral administration of injected vitamin B12
Commonly reported
- Mostly gastrointestinal: nausea, vomiting, diarrhea, constipation, and abdominal pain
- Alongside that, soreness or redness where you inject
Pancreatitis history and pregnancy plans are reviewed before anything is prescribed. Injected vitamin B12 carries its own labeled cautions. Those risks are described for the individual components rather than for this compounded combination, which has no safety database of its own. Your clinician is the one who decides whether it belongs in your case.
Questions
Asked and answered.
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