METABOLIC
Semaglutide
Explore compounded semaglutide injections for weight management, with clinical review, medication, shipping and ongoing care in one monthly plan.
From $129/mo
Injection
Tirzepatide + B12 Microdose
A lower-dose compounded tirzepatide and vitamin B12 injection, with individual prescribing, pharmacy fulfillment and follow-up.
Your treatment plan
From $149/month equivalent
$447 billed every 3 months3-month commitment$179 billed monthly also availableAll fees includedView plan details
- Licensed clinicians
- Compounded by a licensed 503A pharmacy
- No clinic visit
Alternate dosage forms are compounded only where a licensed clinician documents a patient-specific clinical need that a commercially available product cannot meet. They are not interchangeable with, and are not substitutes for, FDA-approved products. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality.
Questions before you start?
Compare this treatmentWhat will I pay?
Standard plan price$149 per month equivalent, billed $447 every 3 months. 3-month commitment.
Billing options and renewal
The standard Tirzepatide + B12 Microdose price is $179 billed monthly, or $447 paid up front every three months ($149 per month equivalent; a three-month commitment). These are recurring prices before any eligible first-order discount. A first-order offer reduces that order only; renewal uses the standard price for the chosen plan. A monthly equivalent is not a monthly charge.
What should I know about this treatment?
A lower-dose compounded tirzepatide and vitamin B12 injection, with individual prescribing, pharmacy fulfillment and follow-up.
Read the evidence and its limitationsWhat should I review before starting?
Boxed warning
FDA-approved tirzepatide products carry a boxed warning about thyroid C-cell tumors observed in rats; whether tirzepatide causes these tumors in humans is unknown.
A licensed clinician reviews your health history and medications and determines whether treatment is appropriate for you.
Read the full Important Safety InformationHow do I request Tirzepatide + B12 Microdose online?
Complete the online assessment with your health history, current medications and treatment goals. A licensed clinician reviews the information and decides whether to prescribe. If prescribed, a licensed pharmacy prepares and ships your medication.
See how care worksWhat It Is
A lower dose is still an individual decision.
This compounded injection combines tirzepatide and vitamin B12. “Microdose” is the name used for this lower-dose option; it is not a standardized FDA-approved GLP-1 dosing category.
Your clinician considers your treatment history, response, tolerability and the medical reason for the combination. The prescribed dose comes from that evaluation, not from the product name or an online dosing chart.
Vitamin B12 is an essential nutrient. Adding it does not establish greater weight loss or fewer side effects, and a lower dose does not guarantee the results reported for approved medicines.
Your plan includes clinical review, prescribed medication, pharmacy fulfillment, shipping and care-team messaging. This compounded preparation is not FDA-approved.
Read the evidenceWho It's For
For the case that needs more than a standard template.
01
The Individualized Case
A standard finished product does not answer a documented prescribing need. You want the formulation decision made from your medical history rather than from a product menu.
02
The Prior Incretin Patient
Your past response and tolerability give your clinician real information to work with. The next prescription should use that information, not ignore it.
03
The Holding Pattern
During care, a provider may determine that a reduced-dose phase fits the patient's current clinical picture. The dose is set by the provider and is not an entry point selected at signup.
This lower-dose compounded preparation is not FDA-approved. Your clinician evaluates the individual need for the formulation; lower dosing does not guarantee fewer side effects.
This might not be the right fit if:
- You have a personal or family history of medullary thyroid carcinoma or MEN 2.
- You are pregnant, planning pregnancy, or breastfeeding.
- You have a history of pancreatitis that has not been reviewed with your clinician.
- You have severe gastroparesis or another severe gastrointestinal motility disorder.
- You have a known hypersensitivity to tirzepatide, vitamin B12, cobalt, or another component of the preparation.
Your intake screens for all contraindications. Every candidate is evaluated by a licensed clinician before any prescription is issued. No prescription is issued without clearance.
Your Plan
Tirzepatide + B12 Microdose, prescribed with care.
Compounded by a licensed 503A pharmacy. Prescribed by a licensed provider after clinical review.
- Format
- Injection
- Strength
- Tirzepatide 5 mg/mL with B12
- Total plan quantity
- 3 vials
- Billed amount
- $447 every 3 months
- Monthly equivalent
- $149 per month
- Commitment
- 3 months
- Monthly option
- $179 billed monthly · 1 vial total plan quantity
- Fees
- Included in the plan price
Strength describes the preparation. Total plan quantity is the amount included in that plan, not your dose or dosing schedule. Follow the directions on your prescription.
Compounded by a licensed 503A pharmacy
Tirzepatide + B12 Microdose
Injection
From $149
Monthly equivalent. All fees included.
$447 billed every 3 months. 3-month commitment.
- Licensed provider review of your history, medications, goals, and prior incretin response
- Documented clinical rationale for the compounded formulation
- Individual prescription prepared by a licensed 503A pharmacy if approved
- Treatment changes remain clinician-directed rather than self-selected
- Ongoing follow-up connected to the broader metabolic plan
$149 /mo equivalent · 3-month commitment
$149/mo equivalent, all-in. Consultation is included in the plan price, not added on top. Consultation, cancellation and refund policy.
What happens when I start?
You'll begin an online assessment for Tirzepatide + B12 Microdose.
- Tell your clinician about you. Share your goals, health history and current medications.
- Review your plan. Confirm the treatment option, billing interval and total shown in the assessment.
- Get an individual clinical review. Your clinician decides whether to prescribe. If prescribed, a licensed pharmacy fulfills your prescription.
Starting an assessment doesn't guarantee a prescription. How care works
Alternate dosage forms are compounded only where a licensed clinician documents a patient-specific clinical need that a commercially available product cannot meet. They are not interchangeable with, and are not substitutes for, FDA-approved products. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality.
*Price reflects a 3-month commitment. See billing details above.
Your subscription renews at your selected billing interval. Cancel through your member dashboard before the next billing date to stop future charges. Cancellation does not refund the current billing period. See cancellation and refund terms.
Have a question about this plan?
Clinical questions
Message your provider about dosing, side effects, your response or changes in your health.
Open patient portalNew to AnthologyRX? Ask our team about getting started.
Care and cost
Clear pricing. Care that follows through.
Your plan brings the clinical review, prescribed medication, pharmacy fulfillment, shipping and care-team messaging together. The consultation is included in your plan price.
- What will I pay at the start and on renewal?
- $179 billed monthly, or $447 paid up front every three months ($149/month equivalent; three-month commitment). These are the standard recurring prices, before any eligible first-order discount. The monthly equivalent is not a monthly charge.
- Does a dose change affect the price?
- The displayed price is for the Tirzepatide + B12 Microdose plan and selected billing interval. Confirm the prescribed strength, quantity and price before starting or changing treatment. Moving to a different product or formulation can change the cost. Your clinician decides whether a dose change is appropriate.
- How is this formulation different?
- This lower-dose injection combines tirzepatide with vitamin B12. “Microdose” is not a standardized FDA-approved dosing category. Your clinician evaluates the reason for this combination and the prescribed dose. Explore our other tirzepatide preparations: Tirzepatide injections or Dissolving tablets. Each requires its own clinical evaluation.
- Who helps when I have a question?
- Use the patient portal for questions about dosing, side effects or changes in your health. AnthologyRX support can help with billing, shipping and portal access.
The people behind your care
Guidance from the first question onward.
Independent clinical care
Licensed clinicians affiliated with Arora Health & Aesthetics, LLC review your health history, medications and goals, then discuss whether Tirzepatide + B12 Microdose or another approach fits your needs.
Medical information on this page reviewed by Dr. Dylan Russell, MD, Chief Health Officer on . Your prescribing clinician provides your individual care.
Verify Dr. Russell's medical licensePharmacy quality that matters
Prepared to your prescription by a licensed compounding pharmacy. Our partners have verified quality programs covering identity, potency, independent testing and batch documentation, with sterility and endotoxin controls for injectable preparations.
Compounded preparations are not FDA-approved. Pharmacy quality controls and your clinician's evaluation of treatment evidence each have a role in your care.
Pharmacy & fulfillment
Listed dispensing pharmacy
- BelieveRXFormulation: Tirzepatide + B12 Microdose, injectionVerify: Texas pharmacy license 35264
Availability depends on your prescription and location. For pharmacy questions, contact our team.
A direct line for follow-up
Message your provider through the patient portal about dosing, side effects, your response or changes in your health. Contact AnthologyRX support for billing, shipment or portal-access help.
The Evidence
What the research shows
One peptide activates both incretin receptors, with a half-life of about five days.
Both native incretin receptors
the GIP and GLP-1 receptors, the targets of the two native incretin hormones
The detail
Tirzepatide is a single peptide that binds to and activates both the GIP receptor and the GLP-1 receptor, the targets of the two native incretin hormones, and it carries a C20 fatty diacid that enables albumin binding and an elimination half-life of approximately five days, which labeling describes as what enables once-weekly dosing of the approved product.1
Tirzepatide raises insulin, lowers glucagon and delays gastric emptying most after the first dose.
The detail
Approved tirzepatide labeling states that the molecule enhances insulin secretion and reduces glucagon, both in a glucose-dependent manner, and that it delays gastric emptying, an effect largest after the first dose that diminishes over time.1
Labeling ties GLP-1 to appetite; the GIP contribution rests on nonclinical studies.
The detail
Labeling further describes GLP-1 as a physiological regulator of appetite and caloric intake, notes that GIP and GLP-1 receptors are found in areas of the brain involved in appetite regulation, and attributes the further contribution of GIP to food-intake regulation to nonclinical studies.2
Vitamin B12 has no incretin activity; it is an enzyme cofactor.
The detail
Vitamin B12 has no incretin receptor activity. It functions as a cofactor for two enzymes, methionine synthase and L-methylmalonyl-CoA mutase, and is required for red blood cell formation, DNA synthesis, and the development, myelination and function of the central nervous system.3
Injected vitamin B12 bypasses the intrinsic factor that gut absorption depends on.
The detail
Injectable cyanocobalamin labeling states that vitamin B12 is rapidly absorbed from intramuscular and subcutaneous sites of injection, whereas gastrointestinal absorption of vitamin B12 depends on sufficient intrinsic factor, which is the pharmacologic reason an injectable route is used at all.4
What it does not show
A compounded preparation is not an FDA-approved drug product.
The detail
A compounded preparation is not an FDA-approved drug product, and FDA does not verify the safety, effectiveness or quality of a compounded drug before it is marketed.5
This block describes mechanism only and reports no trial result.
The detail
Every mechanism statement above is drawn from the clinical pharmacology section of approved labeling and from equivalent pharmacology sources, sections that are separate from the clinical studies section of the same labeling. This block deliberately describes how each ingredient works and does not report what any trial measured.1
Dual agonism is a binding property, not a claim of superior results.
The detail
Dual agonism means one molecule occupies two incretin receptors, a property characterized in vitro through receptor-occupancy analysis and cell signalling assays. It is a statement about receptor binding rather than a claim of results superior to agonism at the GLP-1 receptor alone.6
Vitamin B12 has no established effect on body weight.
The detail
Injectable vitamin B12 labeling gives treatment of vitamin B12 deficiency states as its indication and describes no effect of vitamin B12 on body weight. Adding vitamin B12 to a preparation has no established effect on weight.4
No source here describes the compounded tirzepatide and vitamin B12 preparation itself.
The detail
The labeling relied on above describes an approved single-ingredient tirzepatide product, including its pharmacokinetics and dosing interval. It does not describe a compounded tirzepatide and vitamin B12 preparation, and no source cited here characterizes the exposure produced by such a preparation.1
- FDA-approved tirzepatide injection prescribing information, sections…DailyMed
- FDA-approved tirzepatide injection prescribing information, section…DailyMed
- National Institutes of Health, Office of Dietary Supplements. Vitamin B12: fact sheet for health professionals.Source
- FDA-approved cyanocobalamin injection, USP prescribing information…DailyMed
- FDA, Compounding and the FDA: Questions and Answers.FDA
- Willard FS, Douros JD, Gabe MB, et al. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor… JCI Insight. 2020. In vitro receptor pharmacology.
Important Safety Information
Boxed warning
FDA-approved tirzepatide products carry a boxed warning about thyroid C-cell tumors observed in rats; whether tirzepatide causes these tumors in humans is unknown.
Do not use if you have
- A personal or family history of medullary thyroid carcinoma or MEN 2
- Sensitivity to cobalt or vitamin B12
Serious risks
- Pancreatitis
- Gallbladder disease
- Severe gastrointestinal reactions
- Kidney injury related to dehydration
- Hypoglycemia when tirzepatide is used with insulin or insulin secretagogues
- Serious hypersensitivity reactions have been reported after parenteral administration of injected vitamin B12
Commonly reported
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain
- Indigestion
- Soreness where you inject
Reported effects are mostly gastrointestinal, along with soreness where you inject. The important risks are in tirzepatide labeling. That warning is why pregnancy plans, pancreatitis history, gastrointestinal motility disease, and glucose-lowering medications are reviewed first. Injected vitamin B12 adds its own labeled cautions. Those risks are described for the individual components rather than for this compounded combination, which is one more reason the prescribing decision stays with a clinician.
Questions
Asked and answered.
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