RECOVERY & REPAIR
BPC-157
Compounded BPC-157 sourced through a licensed US pharmacy and placed inside clinician review, not a research-vendor checkout.
From $179/mo
Oral
Methylene Blue
Pharmaceutical-grade compounded methylene blue with medication screening and clinician-directed dosing.
Your treatment plan
From $159/month equivalent
$477 billed every 3 months3-month commitment$189 billed monthly also availableAll fees includedView plan details
- Licensed clinicians
- Compounded by a licensed 503A pharmacy
- No clinic visit
Questions before you start?
Compare this treatmentWhat will I pay?
Standard plan price$159 per month equivalent, billed $477 every 3 months. 3-month commitment.
Billing options and renewal
The standard Methylene Blue price is $189 billed monthly, or $477 paid up front every three months ($159 per month equivalent; a three-month commitment). These are recurring prices before any eligible first-order discount. A first-order offer reduces that order only; renewal uses the standard price for the chosen plan. A monthly equivalent is not a monthly charge.
What should I know about this treatment?
Pharmaceutical-grade compounded methylene blue with medication screening and clinician-directed dosing.
Read the evidence and its limitationsWhat should I review before starting?
Boxed warning
The interaction is the headline. Methylene blue inhibits monoamine oxidase, and the approved injectable product carries a boxed warning about serotonin syndrome when it is combined with SSRIs, SNRIs, MAOIs, opioids or dextromethorphan; some reported cases were fatal, and the labeling advises avoiding serotonergic medicines for 72 hours after the last dose.
A licensed clinician reviews your health history and medications and determines whether treatment is appropriate for you.
Read the full Important Safety InformationHow do I request Methylene Blue online?
Complete the online assessment with your health history, current medications and treatment goals. A licensed clinician reviews the information and decides whether to prescribe. If prescribed, a licensed pharmacy prepares and ships your medication.
See how care worksWhat It Is
Interesting mechanism. Serious interaction profile.
Methylene blue has been part of medicine and laboratory science for more than a century. Its longevity-era relevance comes from a much newer conversation: research examining the compound in mitochondrial electron transport, the chain cells use to move electrons during energy production.
That mechanism is interesting without establishing a benefit for memory, focus, energy, or lifespan.
The reason this product belongs inside prescription care is just as important as the reason people read about it. Methylene blue has meaningful medication interactions and can be unsafe in specific conditions. Serotonergic medications and G6PD deficiency are not footnotes to a wellness compound. They can change whether the prescription belongs in your plan at all.
Compounding gives your clinician a way to prescribe an individualized oral formulation when off-label use is judged appropriate, with the rest of your medications and health history reviewed before the prescription moves forward.
The strange and serious parts deserve plain language. Pharmaceutical-grade sourcing, blue discoloration, G6PD screening, and SSRI or serotonin interactions are part of responsible medical use, not details to discover after the prescription arrives.
Read the evidenceWho It's For
For the person who would only consider methylene blue medically.
01
The Precision-Minded Reader
You have seen methylene blue sold in places that make the molecule look far more casual than it is. You want the version that begins with a prescription decision, not a bottle sourced on trust.
02
The Safety-Serious Reader
The mitochondrial mechanism caught your attention, but the interaction profile is why you will not treat methylene blue like a supplement. You want the science and the medication review considered together.
03
The Carefully Medicated Patient
You take other prescriptions and know that interactions can matter more than the headline benefit. You want someone to review the full medication list before the molecule gets anywhere near the plan.
Compounded methylene blue is not an FDA-approved drug product. A licensed provider reviews everything you take, especially antidepressants and other serotonergic medications, and determines whether you are a candidate at all.
This might not be the right fit if:
- Current use of serotonergic medications including SSRIs, SNRIs, or MAOIs, given the risk of serotonin syndrome
- G6PD deficiency, where methylene blue can trigger hemolysis
- Pregnancy or breastfeeding
- Known hypersensitivity to methylene blue
- Significant kidney impairment without specialist oversight
Your intake screens for all contraindications. Every candidate is evaluated by a licensed clinician before any prescription is issued. No prescription is issued without clearance.
Your Plan
Methylene Blue, prescribed with care.
Compounded by a licensed 503A pharmacy. Prescribed by a licensed provider after clinical review.
- Format
- Oral
- Strength
- 15 mg capsules
- Total plan quantity
- 90 capsules
- Billed amount
- $477 every 3 months
- Monthly equivalent
- $159 per month
- Commitment
- 3 months
- Monthly option
- $189 billed monthly · 30 capsules total plan quantity
- Fees
- Included in the plan price
Strength describes the preparation. Total plan quantity is the amount included in that plan, not your dose or dosing schedule. Follow the directions on your prescription.
Compare billing options and longer-term costs
Compounded by a licensed 503A pharmacy
Methylene Blue
Oral
From $159
Monthly equivalent. All fees included.
$477 billed every 3 months. 3-month commitment.
- Mitochondrial electron transport described as a mechanism, not an outcome promise
- Compounded oral formulation prepared to your individual prescription
- Medication and medical history reviewed before prescribing
- Serotonergic medications and G6PD deficiency screened before treatment
$159 /mo equivalent · 3-month commitment
$159/mo equivalent, all-in. Consultation is included in the plan price, not added on top. Consultation, cancellation and refund policy.
What happens when I start?
You'll begin an online assessment for Methylene Blue.
- Tell your clinician about you. Share your goals, health history and current medications.
- Review your plan. Confirm the treatment option, billing interval and total shown in the assessment.
- Get an individual clinical review. Your clinician decides whether to prescribe. If prescribed, a licensed pharmacy fulfills your prescription.
Starting an assessment doesn't guarantee a prescription. How care works
Prescription issued subject to provider judgment. Results vary. Not a guarantee of outcomes.
*Price reflects a 3-month commitment. See billing details above.
Your subscription renews at your selected billing interval. Cancel through your member dashboard before the next billing date to stop future charges. Cancellation does not refund the current billing period. See cancellation and refund terms.
Have a question about this plan?
Clinical questions
Message your provider about dosing, side effects, your response or changes in your health.
Open patient portalNew to AnthologyRX? Ask our team about getting started.
The people behind your care
Guidance from the first question onward.
Independent clinical care
Licensed clinicians affiliated with Arora Health & Aesthetics, LLC review your health history, medications and goals, then discuss whether Methylene Blue or another approach fits your needs.
Medical information on this page reviewed by Dr. Dylan Russell, MD, Chief Health Officer on . Your prescribing clinician provides your individual care.
Verify Dr. Russell's medical licensePharmacy quality that matters
Prepared to your prescription by a licensed compounding pharmacy. Our partners have verified quality programs covering identity, potency, independent testing and batch documentation.
Compounded preparations are not FDA-approved. Pharmacy quality controls and your clinician's evaluation of treatment evidence each have a role in your care.
Pharmacy & fulfillment
Listed dispensing pharmacy
- Partell Pharmacy / National Health RXFormulation: Methylene Blue, oralThis option is not available in Louisiana, Mississippi, or Washington.Verify: Nevada pharmacy license PH02028
Availability depends on your prescription and location. For pharmacy questions, contact our team.
A direct line for follow-up
Message your provider through the patient portal about dosing, side effects, your response or changes in your health. Contact AnthologyRX support for billing, shipment or portal-access help.
The Evidence
What the research shows
The approved product is an injection for acquired methemoglobinemia.
31 adults
the patients behind the approval for acquired methemoglobinemia
The detail
The FDA-approved methylene blue product is an injection, and its approved indication is the treatment of acquired methemoglobinemia in pediatric and adult patients, given as 1 mg per kilogram intravenously over 5 to 30 minutes; the efficacy behind that approval was established in 31 adult patients with acquired methemoglobinemia, studied across a prospective open-label single-arm trial and a prospective multicenter observational registry.1
A single oral dose raised fMRI response and correct answers on a memory task.
7 percent
increase in correct responses during memory retrieval, one hour after dosing
The detail
In a randomized, double-blind, placebo-controlled trial in 26 healthy adults aged 22 to 62, a single 280 mg oral dose of USP methylene blue increased functional MRI response during a sustained-attention task and a short-term memory task one hour after dosing, and was associated with a 7 percent increase in correct responses during memory retrieval.23
In bipolar disorder, depression and anxiety improved, but cognitive symptoms did not.
195 mg vs 15 mg
active daily dose against the control dose over six months
The detail
In a 6-month double-blind crossover trial in 37 patients with bipolar disorder already treated with lamotrigine, methylene blue at an active dose of 195 mg daily improved symptoms of depression and anxiety compared with a 15 mg control dose, while its effects on cognitive symptoms were not statistically significant.4
In cells and rodents, methylene blue acted as an alternative mitochondrial electron carrier.
The detail
In cultured neuronal cells and in rodent models of Parkinson disease and transient focal cerebral ischemia, methylene blue acted as an alternative mitochondrial electron carrier, accepting electrons from NADH and transferring them to cytochrome c to bypass blockade of complexes I and III.5
In cultured human cells, lifespan extended by more than 20 population doublings.
30 percent
increase in mitochondrial complex IV in cultured fibroblasts
The detail
In cultured human IMR90 fibroblasts, nanomolar methylene blue extended the culture lifespan by more than 20 population doublings, increased mitochondrial complex IV by 30 percent and raised cellular oxygen consumption by 37 to 70 percent.6
What it does not show
No approved indication for cognition, focus, energy, mitochondrial function or aging.
The detail
The approved indication and the reason people are interested in this molecule are not the same thing. No FDA-approved methylene blue product carries an indication for cognition, focus, energy, mitochondrial function or aging, the approved product is an injection used for acquired methemoglobinemia, and a compounded oral preparation is not an FDA-approved drug product.1
Oral dosing produced far lower exposure than intravenous dosing of the same 100 mg.
9 vs 137
nmol/min/mL area under the curve, oral against intravenous
The detail
Route and dose do not carry over. In seven volunteers given 100 mg of methylene blue by both routes, the area under the whole-blood concentration-time curve after oral dosing was 9 nmol/min/mL compared with 137 nmol/min/mL after intravenous dosing, and in the rat arm of the same study intraduodenal dosing produced lower brain concentrations than intravenous dosing.7
No trial has tested oral methylene blue taken daily for memory, focus or energy.
26 people
the whole human cognitive signal, from a single dose measured one hour later
The detail
The human cognitive signal is a single dose, measured one hour later, in 26 people, largely by brain imaging. No randomized trial has tested oral methylene blue taken daily over weeks or months for memory, focus, energy or any aging-related outcome in healthy adults, and the one trial that did run six months, in patients with bipolar disorder, found no significant effect on cognitive symptoms.24
Tested at scale in Alzheimer’s disease, a related compound showed no benefit.
891 patients
across 115 sites, with no benefit on either co-primary endpoint
The detail
Where a methylthioninium compound was tested at scale, it did not work. In a 15-month randomized, controlled, double-blind, parallel-arm phase 3 trial at 115 sites in 891 patients with mild to moderate Alzheimer’s disease, leuco-methylthioninium, a stable reduced form of the methylthioninium moiety in methylene blue, showed no benefit on either co-primary endpoint at either dose tested.8
- FDA-approved prescribing information, PROVAYBLUE (methylene blue) injection, American Regent, Inc., label published May 2025.DailyMed
- Rodriguez P, Zhou W, Barrett DW, et al. Multimodal randomized functional MR imaging of the effects of methylene… Radiology. 2016.
- Effects of USP Methylene Blue on Cognitive and fMRI Brain Activity…ClinicalTrials.gov
- Alda M, McKinnon M, Blagdon R, et al. Methylene blue treatment for residual symptoms of bipolar disorder… Br J Psychiatry. 2017.
- Wen Y, Li W, Poteet EC, et al. Alternative mitochondrial electron transfer as a novel strategy for… J Biol Chem. 2011.
- Atamna H, Nguyen A, Schultz C, et al. Methylene blue delays cellular senescence and enhances key… FASEB J. 2008.
- Peter C, Hongwan D, Küpfer A, Lauterburg BH. Pharmacokinetics and organ distribution of intravenous and oral… Eur J Clin Pharmacol. 2000.
- Gauthier S, Feldman HH, Schneider LS, et al. Efficacy and safety of tau-aggregation inhibitor therapy in patients… Lancet. 2016.
Important Safety Information
Boxed warning
The interaction is the headline. Methylene blue inhibits monoamine oxidase, and the approved injectable product carries a boxed warning about serotonin syndrome when it is combined with SSRIs, SNRIs, MAOIs, opioids or dextromethorphan; some reported cases were fatal, and the labeling advises avoiding serotonergic medicines for 72 hours after the last dose.
Do not use if you have
- Contraindicated in G6PD deficiency, because it can cause hemolysis
Commonly reported
- It turns urine, and sometimes stools, blue to blue-green while interfering with pulse oximetry readings and urine dipstick tests
- Headache
- Nausea
- Diarrhea
- Dizziness
- Sensitivity to light
- Shifts in potassium and magnesium
Your provider goes through your full medication list, including over-the-counter cough preparations, and screens for G6PD deficiency and kidney impairment before prescribing, because that safety record comes from the approved injectable used for methemoglobinemia and not from oral methylene blue taken this way.
Questions
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