SEXUAL VITALITY
PT-141
Explore a different approach to low sexual desire. Compounded prescription PT-141, with individualized clinician guidance and follow-up included.
From $129/mo
Oral tablet
Tadalafil 20mg On-Demand
On-demand tadalafil pairs an established FDA-approved generic with a longer activity profile than sildenafil.
Your treatment plan
From $29/month equivalent
$87 billed every 3 months3-month commitment$49 billed monthly also availableAll fees includedView plan details
- Licensed clinicians
- FDA-approved generic medication
- No clinic visit
- Generic for Cialis
Questions before you start?
Compare this treatmentWhat will I pay?
Standard plan price$29 per month equivalent, billed $87 every 3 months. 3-month commitment.
Billing options and renewal
The standard Tadalafil 20mg On-Demand price is $49 billed monthly, or $87 paid up front every three months ($29 per month equivalent; a three-month commitment). These are recurring prices before any eligible first-order discount. A first-order offer reduces that order only; renewal uses the standard price for the chosen plan. A monthly equivalent is not a monthly charge.
What should I know about this treatment?
On-demand tadalafil pairs an established FDA-approved generic with a longer activity profile than sildenafil.
Read the evidence and its limitationsWhat should I review before starting?
A licensed clinician reviews your health history and medications and determines whether treatment is appropriate for you.
Read the full Important Safety InformationHow do I request Tadalafil 20mg On-Demand online?
Complete the online assessment with your health history, current medications and treatment goals. A licensed clinician reviews the information and decides whether to prescribe. If prescribed, a licensed pharmacy prepares and ships your medication.
See how care worksWhat It Is
A longer window for what happens next.
On-demand tadalafil helps you get and maintain an erection with sexual stimulation. Its effect on erectile function has been demonstrated for up to 36 hours after a dose, giving intimacy more flexibility around timing. That is a response window, not a continuous erection.3
Tadalafil is the active ingredient in Cialis. AnthologyRX offers the FDA-approved generic for use before anticipated sexual activity, following your prescription. Food does not meaningfully affect its absorption.3
If you prefer to separate medication from each occasion altogether, daily tadalafil offers another routine. The choice depends on your preferences, response, side effects, and medical history.
- FDA-approved prescribing information, CIALIS (tadalafil) tablets, Eli Lilly and Company, label published June 2026.DailyMed
Who It's For
For men who want a window, not a stopwatch.
01
The Anti-Scheduler
You want on-demand treatment without making intimacy obey a narrow clock. Tadalafil gives the clinician a longer-acting option to consider.
02
The Occasional User
You do not want a medication in your routine every day. You want treatment available when it is relevant and out of mind when it is not.
03
The Sildenafil Switcher
Sildenafil worked, but the timing felt too precise. A longer-acting molecule may fit your life better even when the underlying treatment goal is the same.
Bring your history with ED treatment, if any, to the Assessment. A licensed clinician determines whether this dose suits your health profile.
This might not be the right fit if:
- Any use of nitrate medications, including nitroglycerin and isosorbide; combining tadalafil with nitrates can cause a dangerous drop in blood pressure
- Recent heart attack or stroke, or cardiac status your provider considers unstable
- Severe hypotension, or blood pressure that is not adequately controlled
- Alpha-blocker therapy requires provider caution around dosing and timing
- Use of riociguat, or a prior serious reaction to tadalafil
Your intake screens for all contraindications. Every candidate is evaluated by a licensed clinician before any prescription is issued. No prescription is issued without clearance.
Your Plan
Tadalafil 20mg On-Demand, prescribed with care.
FDA-approved generic medication. Prescribed by a licensed provider after clinical review.
- Format
- Oral tablet
- Strength
- 20 mg
- Total plan quantity
- 48 tablets
- Billed amount
- $87 every 3 months
- Monthly equivalent
- $29 per month
- Commitment
- 3 months
- Monthly option
- $49 billed monthly · 16 tablets total plan quantity
- Fees
- Included in the plan price
Strength describes the preparation. Total plan quantity is the amount included in that plan, not your dose or dosing schedule. Follow the directions on your prescription.
Compare billing options and longer-term costs
FDA-approved generic medication
Tadalafil 20mg On-Demand
Oral tablet
From $29
Monthly equivalent. All fees included.
$87 billed every 3 months. 3-month commitment.
- Licensed clinician review of cardiovascular history and current medications
- On-demand tadalafil prescribed only when the clinician determines it is appropriate
- Nitrates and other important interaction risks screened before prescribing
- Ongoing access for response, tolerability, and treatment-pattern changes
$29 /mo equivalent · 3-month commitment
$29/mo equivalent, all-in. Consultation is included in the plan price, not added on top. Consultation, cancellation and refund policy.
What happens when I start?
You'll begin an online assessment for Tadalafil 20mg On-Demand.
- Tell your clinician about you. Share your goals, health history and current medications.
- Review your plan. Confirm the treatment option, billing interval and total shown in the assessment.
- Get an individual clinical review. Your clinician decides whether to prescribe. If prescribed, a licensed pharmacy fulfills your prescription.
Starting an assessment doesn't guarantee a prescription. How care works
Prescription issued subject to provider judgment. Results vary. Not a guarantee of outcomes.
*Price reflects a 3-month commitment. See billing details above.
Your subscription renews at your selected billing interval. Cancel through your member dashboard before the next billing date to stop future charges. Cancellation does not refund the current billing period. See cancellation and refund terms.
Have a question about this plan?
Clinical questions
Message your provider about dosing, side effects, your response or changes in your health.
Open patient portalNew to AnthologyRX? Ask our team about getting started.
The people behind your care
Guidance from the first question onward.
Independent clinical care
Licensed clinicians affiliated with Arora Health & Aesthetics, LLC review your health history, medications and goals, then discuss whether Tadalafil 20mg On-Demand or another approach fits your needs.
Medical information on this page reviewed by Dr. Dylan Russell, MD, Chief Health Officer on . Your prescribing clinician provides your individual care.
Verify Dr. Russell's medical licensePrescription pharmacy care
Tadalafil 20mg On-Demand is offered as an FDA-approved generic medication, dispensed by a licensed pharmacy after your clinician issues a prescription.
Your clinician explains the intended use, including whether it falls outside the medication's FDA-approved indications.
Pharmacy & fulfillment
Listed dispensing pharmacy
- HealthWarehouse.comFormulation: 20 mg tabletsVerify: Oklahoma nonresident pharmacy permit 99-7707
Availability depends on your prescription and location. For pharmacy questions, contact our team.
A direct line for follow-up
Message your provider through the patient portal about dosing, side effects, your response or changes in your health. Contact AnthologyRX support for billing, shipment or portal-access help.
The Evidence
What the research shows
81 percent of men on tadalafil reported improved erections, against 35 percent on placebo.
81% vs 35%
men reporting improved erections at endpoint, tadalafil 20 mg versus placebo
The detail
In an integrated analysis of five randomized, double-blind, placebo-controlled 12-week trials in 1112 men of mean age 59 with mild to severe erectile dysfunction of various causes, tadalafil 20 mg taken as needed produced a mean improvement of 7.9 points in the International Index of Erectile Function erectile-function domain from baseline, 75 percent of intercourse attempts were completed successfully on the Sexual Encounter Profile question 3, and 81 percent of men reported improved erections at endpoint compared with 35 percent on placebo.1
At 36 hours after a dose, 59.2 percent of attempts succeeded versus 28.3 on placebo.
59.2% vs 28.3%
successful intercourse attempts 36 hours after a dose, tadalafil versus placebo
The detail
In a multicenter randomized, double-blind, placebo-controlled trial in 348 men in Europe and the United States, participants were assigned to attempt intercourse approximately 24 or 36 hours after a dose. At 36 hours, 59.2 percent of attempts were successful on tadalafil 20 mg versus 28.3 percent on placebo; at 24 hours, 52.9 percent versus 29.1 percent.2
The approved as-needed programme runs to 22 trials and over 4000 patients.
22 trials · 4000 patients
in the as-needed programme described by FDA labeling, up to 24 weeks
The detail
The FDA-approved labeling describes an as-needed programme of 22 clinical trials of up to 24 weeks involving over 4000 patients, including seven randomized, multicenter, double-blind, placebo-controlled, parallel-arm 12-week studies in the general erectile-dysfunction population, with three co-primary outcomes: the erectile-function domain of the International Index of Erectile Function and Sexual Encounter Profile questions 2 and 3.3
Tadalafil 10 mg sat mid-pack on efficacy with the lowest overall adverse-event rate.
82 trials · 47,626 patients
randomized evidence pooled across the starting doses compared
The detail
In a network meta-analysis of 82 randomized trials covering 47,626 patients, tadalafil 10 mg had intermediate efficacy among the starting doses compared and the lowest overall rate of adverse events, while sildenafil 50 mg had the greatest efficacy and the highest overall adverse-event rate.4
Men stayed on tadalafil on demand longer than on sildenafil before stopping.
168 vs 67 days
median time to discontinuation, tadalafil 10 mg on demand versus sildenafil 50 mg
The detail
In an open-label randomized study in 770 men new to PDE5 inhibitors, median time to discontinuation of the assigned treatment was longer than 168 days for tadalafil 10 mg on demand and 130 days for tadalafil 5 mg once daily, compared with 67 days for sildenafil 50 mg on demand. Reported reasons for stopping that differed significantly between groups included lack of duration of erection and time constraints from a short window of action.5
What it does not show
At 36 hours, roughly four in ten attempts did not succeed.
four in ten
attempts at approximately 36 hours that did not succeed
The detail
The 36-hour figure is a measured window of responsiveness, not a promise about an erection. In the trial that produced it, men were instructed to attempt intercourse at approximately 36 hours after dosing and 59.2 percent of those attempts succeeded, which means roughly four in ten did not. Nothing in that design establishes 36 hours of continuous effect.2
Placebo attempts succeeded too, and 35 percent on placebo reported improved erections.
28.3 and 29.1 percent
of placebo attempts succeeded in the same 24 and 36 hour trial
Tadalafil does not cure erectile dysfunction and does not increase sexual desire.
The detail
The endpoints are self-reported intercourse success and questionnaire scores over 12 to 24 weeks. They do not establish an effect on desire. The FDA-approved labeling states that tadalafil has no effect in the absence of sexual stimulation, and the patient labeling states plainly that the medication does not cure erectile dysfunction and does not increase sexual desire.13
Superiority over the alternatives is not established; only time on treatment differed.
9.4 to 10.0
least-squares means across the three arms, p equals 0.359
The detail
Superiority over the alternatives is not established. In the randomized comparison of tadalafil on demand, tadalafil once daily and sildenafil on demand, improvement in the erectile-function domain did not differ between the three arms, least-squares means 9.4 to 10.0, p equals 0.359; what differed was how long men stayed on treatment. The labeling also states that combinations of tadalafil with other PDE5 inhibitors or other erectile-dysfunction treatments have not been studied.35
- Brock GB, McMahon CG, Chen KK, Costigan T, Shen W, Watkins V, Anglin G, Whitaker S. Efficacy and safety of tadalafil for the treatment of erectile… J Urol. 2002.
- Porst H, Padma-Nathan H, Giuliano F, Anglin G, Varanese L, Rosen R. Efficacy of tadalafil for the treatment of erectile dysfunction at 24… Urology. 2003.
- FDA-approved prescribing information, CIALIS (tadalafil) tablets, Eli Lilly and Company, label published June 2026.DailyMed
- Chen L, Staubli SE, Schneider MP, Kessels AG, Ivic S, Bachmann LM, Kessler TM. Phosphodiesterase 5 inhibitors for the treatment of erectile… Eur Urol. 2015.
- Buvat J, Buttner H, Hatzimouratidis K, Vendeira PA, Moncada I, Boehmer M, Henneges C, Boess FG. Adherence to initial PDE-5 inhibitor treatment: randomized open-label… J Sex Med. 2013.
Important Safety Information
Do not use if you have
- Nitrates in any form, an exclusion; the labeling advises that at least 48 hours pass after the last dose before nitrate administration is even considered in an emergency
- Riociguat, a guanylate cyclase stimulator, a labeled contraindication for the same reason and an exclusion as well
Serious risks
- An erection lasting longer than four hours needs emergency care
- Sudden loss of vision in one or both eyes, or a sudden decrease or loss of hearing, means stopping the medication and seeking medical attention immediately
- Tadalafil has a long terminal half-life, around 17.5 hours in healthy subjects, so the window in which an interaction can occur is long as well
Commonly reported
- Headache and indigestion are reported most often, followed by back pain, muscle aches, nasal congestion, flushing and limb pain
- Back pain and muscle aches generally began 12 to 24 hours after a dose and typically settled within 48 hours
Alpha-blockers, other blood-pressure medicines, recent cardiac events and the cardiac demand of sexual activity itself are all part of the review before this is prescribed. Tadalafil is an FDA-approved generic dispensed by a licensed US pharmacy, and the dose and the pattern are your clinician's call from your full intake.
Questions
Asked and answered.
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